Thermo Fisher Scientific LRRC8B Polyclonal Antibody
Human LRRC8B 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 용액 형태로 제공. 세포 부피 조절 관련 VRAC 채널 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of the Human LRRC8B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866837 |
Product Specific Information
This antibody reacts with Human and Mouse (species predicted to react based on 100% sequence homology).
Target Information
LRRC8B is a non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), which is required to maintain constant cell volume in response to osmotic changes. VRAC conducts iodide better than chloride and may also conduct organic osmolytes such as taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D, or LRRC8E), and the channel characteristics depend on the precise subunit composition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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