Thermo Fisher Scientific C14orf126 Polyclonal Antibody
Thermo Fisher Scientific의 C14orf126 Polyclonal Antibody는 인간 및 마우스 시료에 반응하며 Western blot에 적합합니다. Rabbit IgG 기반의 비결합형 액상 항체로, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 보관 권장.
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Thermo Fisher Scientific C14orf126 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 136–164 amino acids from the C-terminal region of human C14orf126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541553 |
Target Information
Deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), with no activity on correctly charged L-tyrosyl-tRNA(Tyr). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts toxicity associated with D-aminoacyl-tRNA entities and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to relaxed substrate chirality specificity caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral glycyl-tRNA(Gly) in vitro, though EEF1A1/EF-Tu may protect it from DTD2-mediated deacetylation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-24053_C14orf126_Q96FN9-1_Rabbit.svg, PA5-24053_C14orf126_Q96FN9-1_Rabbit_PDP.jpeg)
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