Thermo Fisher Scientific alpha-1 Antitrypsin Polyclonal Antibody
Alpha-1 Antitrypsin을 검출하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합. 인간 및 일부 포유류 시료에 반응하며, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:250 | - |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified human serum alpha-1-AT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985745 |
Product Specific Information
PA5-16661 targets Alpha-1-Antitrypsin in IHC (P) applications and shows reactivity with Equine, Human, Mink, Monkey, and Baboon samples.
It does not react with Canine, Chicken, Feline, Guinea Pig, Goat, Marsupial, Mouse, Ovine, and Porcine samples.
The immunogen used for PA5-16661 is purified human serum alpha-1-AT.
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of various proteases, including trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin.
In the absence of alpha-1-AT, these enzymes may digest pulmonary parenchyma, leading to tissue damage. Deficiency in alpha-1-AT is associated with chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants and respiratory distress in newborns.
Increased alpha-1-AT levels occur as part of an acute phase response to tissue necrosis and inflammation. Elevated serum levels are observed in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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