Thermo Fisher Scientific DNase I Polyclonal Antibody

Applications

Product Specifications

Target Information

Internucleosomal DNA fragmentation following the activation of endonucleases is the common end point of apoptosis. DNase I, a Ca²⁺/Mg²⁺-dependent endonuclease ubiquitously expressed in mammalian tissues, mediates internucleosomal DNA degradation in human cells undergoing apoptosis. DNase I is highly polymorphic, with at least six known alleles. DNase II, an acidic deoxyribonuclease, acts downstream of caspase activation and also contributes to DNA digestion during apoptosis. DNase I cleaves DNA to 5′-phosphodinucleotide and 5′-phosphooligonucleotide end-products, whereas DNase II produces 3′-phosphomononucleotide and 3′-phosphooligonucleotide end-products. DNase II is usually found in the cytoplasm of epithelial cells but concentrated in nuclei of lens fibers, while DNase I is concentrated in nuclei of epithelial and fiber cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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