Thermo Fisher Scientific SERPINB3 + SERPINB4 Polyclonal Antibody
SERPINB3 및 SERPINB4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간 시료에 반응하며 Protein A로 정제됨. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용.
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- BS-9214R
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human SERPINB3 (same as SERPINB4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Metastasis of a primary tumor to a distant site is determined through signaling cascades that disrupt interactions between cells and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases such as neutrophil elastase.
In 1985, Dr. Jim Travis and Dr. R.W. Carrell identified the serpin family of serine protease inhibitors, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a peptide stretch that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive.
Aberrant expression of serpin family members can contribute to various conditions, including:
- Emphysema (α-1 antitrypsin deficiency)
- Fatal bleeding (elastase to thrombin specificity)
- Thrombosis (antithrombin deficiency)
- Cancer progression (elevated circulating levels of squamous cell carcinoma antigen, SCCA1)
Human chromosome 18q21.3 contains a cluster of serpins, including a tandem duplication of the SCCA gene, plasminogen activator inhibitor type 2, and maspin.
SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2) and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein originally isolated from a metastatic cervical squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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