Thermo Fisher Scientific Phospho-PFKFB2 (Ser483) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC-P)

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the γ phosphate of ATP, onto an acceptor amino acid in a substrate protein. Through this mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
With more than 500 gene products, the protein kinase family is one of the largest in eukaryotes, classified into 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
The AGC kinase group consists of 63 kinases including:

• Cyclic nucleotide-regulated protein kinase (PKA & PKG)
• Diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC)
• Related to PKA and PKC (RAC/Akt) protein kinase family
• Kinases that phosphorylate G protein-coupled receptors (ARK)
• Kinases that phosphorylate ribosomal protein S6 (RSK)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.