Thermo Fisher Scientific TDP-43 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA5-19712 targets TARDBP in IF, IHC (F), IP, and WB applications and shows reactivity with Human and mouse samples.
The immunogen is a synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human TARDBP.
PA5-19712 detects TARDBP, which has a predicted molecular weight of approximately 47 kDa.

Target Information

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR.
Later studies revealed that TDP43 regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), most likely through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U).
TDP43 is distinct from TRBP1, another RNA binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.