Thermo Fisher Scientific CREB Polyclonal Antibody
CREB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고품질 항체. 인간 CREB 단백질에 반응하며 연구용으로만 사용 가능.
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Thermo Fisher Scientific CREB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human CREB fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902499 |
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors. Activation of CREB depends on phosphorylation of serine 133, mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1. While CREB can bind DNA regardless of phosphorylation, only the phosphorylated form acts as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator, interacts with CREB at serine 133. CREB plays roles in circadian rhythm synchronization, adipocyte differentiation, and learning and memory. The human CREB gene is located on chromosome 2q. Dysfunctions are associated with Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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