Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (TCR-3), PE
닭 T세포의 TCR α/β 복합체를 인식하는 단클론 항체로, PE 형광으로 표지되어 유세포분석에 적합합니다. 고순도 정제 항체로 4°C 암소 보관하며, 다양한 포맷으로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 0.5 µg/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Avian, Chicken |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TCR-3 |
| Immunogen | CD3⁺ TCR1⁻ TCR2⁻ Ia⁻ chicken blood mononuclear cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.5, with proprietary stabilizer |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745800 |
Additional Formats
- Unconjugated ([MA5-28843])
- Biotin ([MA5-28839])
- FITC ([MA5-28840])
- PE-Cyanine5 ([MA5-28842])
- Custom conjugation available upon request
Target Information
The T cell antigen receptor (TCR) is a ligand-specific alpha/beta heterodimer associated with invariant CD3 subunits (gamma, delta, eta, zeta). These components are essential for surface expression and signal transduction. Activation through TCR induces T cell differentiation, proliferation, and cytokine production.
Most circulating T cells express TCR alpha/beta heterodimers, while TCR gamma/delta T cells are mainly found in epithelial tissues. Proper assembly of TCR-CD3 complex in the endoplasmic reticulum is required for surface expression. Defects in TCR expression or signaling are linked to immune dysfunction, autoimmune disease, and tumor recognition. Superantigen engagement with TCRs can lead to toxic shock syndrome. Autoantibodies to TCR Vβ segments have been associated with rheumatoid arthritis and systemic lupus erythematosus.
T Cell and TCR Diversity
Most human T cells express TCR alpha-beta with either CD4 or CD8 (single positive). A minor subset lacks both (double negative). Elevated alpha-beta double-negative T cells are observed in autoimmune and immunodeficiency disorders. Gamma-delta T cells, localized mainly in epithelial tissues, exhibit limited TCR diversity and distinct antigen recognition, with roles in antitumor and immunoregulatory functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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