Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (TCR-3), PE

Applications

• Flow Cytometry (Flow): 0.5 µg/10⁶ cells

Product Specifications

Additional Formats

• Unconjugated ([MA5-28843])
• Biotin ([MA5-28839])
• FITC ([MA5-28840])
• PE-Cyanine5 ([MA5-28842])
• Custom conjugation available upon request

Target Information

The T cell antigen receptor (TCR) is a ligand-specific alpha/beta heterodimer associated with invariant CD3 subunits (gamma, delta, eta, zeta). These components are essential for surface expression and signal transduction. Activation through TCR induces T cell differentiation, proliferation, and cytokine production.

Most circulating T cells express TCR alpha/beta heterodimers, while TCR gamma/delta T cells are mainly found in epithelial tissues. Proper assembly of TCR-CD3 complex in the endoplasmic reticulum is required for surface expression. Defects in TCR expression or signaling are linked to immune dysfunction, autoimmune disease, and tumor recognition. Superantigen engagement with TCRs can lead to toxic shock syndrome. Autoantibodies to TCR Vβ segments have been associated with rheumatoid arthritis and systemic lupus erythematosus.

T Cell and TCR Diversity

Most human T cells express TCR alpha-beta with either CD4 or CD8 (single positive). A minor subset lacks both (double negative). Elevated alpha-beta double-negative T cells are observed in autoimmune and immunodeficiency disorders. Gamma-delta T cells, localized mainly in epithelial tissues, exhibit limited TCR diversity and distinct antigen recognition, with roles in antitumor and immunoregulatory functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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