Thermo Fisher Scientific A2M Polyclonal Antibody
Thermo Fisher Scientific의 A2M Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western blot과 ELISA에 적합합니다. Rabbit IgG 폴리클로날 항체로, 고순도 친화 크로마토그래피로 정제되었습니다. 알츠하이머 연구 등 Alpha-2-Macroglobulin 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1155–1474 of human Alpha-2-Macroglobulin (A2M) (NP_0000052) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.44 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913963 |
Product Specific Information
- Positive test controls: SH-SY5Y, Mouse kidney, Mouse ovary, Rat spinal cord
- Localization: Secreted
Immunogen sequence:
ALAGNQDKRK EVLKSLNEEA VKKDNSVHWE RPQKPKAPVG HFYEPQAPSA EVEMTSYVLL AYLTAQPAPT SEDLTSATNI VKWITKQQNA QGGFSSTQDT VVALHALSKY GAATFTRTGK AAQVTIQSSG TFSSKFQVDN NNRLLLQQVS LPELPGEYSM KVTGEGCVYL QTSLKYNILP EKEEFPFALG VQTLPQTCDE PKAHTSFQIS LSVSYTGSRS ASNMAIVDVK MVSGFIPLKP TVKMLERSNH VSRTEVSSNH VLIYLDKVSN QTLSLFFTVL QDVPVRDLKP AIVKVYDYYE TDEFAIAEYN APCSKDLGNA
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits. It shares structural similarity with other alpha-macroglobulins, such as complement components C3 and C4 and pregnancy zone protein (PZP).
A2M acts as a panprotease inhibitor, binding a wide range of ligands and serving as a humoral defense barrier against foreign peptides in plasma. In Alzheimer’s disease patients, A2M localizes to diffuse amyloid plaques, suggesting a role in AD pathogenesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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