Thermo Fisher Scientific KCTD13 Polyclonal Antibody
Human KCTD13 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로 세포 발현 및 단백질 기능 분석에 적합.
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Thermo Fisher Scientific KCTD13 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KCTD13 (Recombinant protein control fragment, Product #RP-98771) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642957 |
Product Specific Information
- Immunogen sequence:
RGEDEENREH RVRRIHVRRH ITHDERPHGQ QIVFKD - Highest antigen sequence identity to the following orthologs:
Mouse – 97%, Rat – 97%
Target Information
Cytochrome P450 super family proteins are monooxygenases that catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids, and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family with a conserved heme-binding domain near the C-terminus. It catalyzes the ω-hydroxylation of LTB4, is localized in the ER, and plays a vital role in inactivation of LTB4 and inflammation control.
CYP4F3 exists in two functionally distinct isoforms:
- CYP4F3A – neutrophil isoform, expressed in neutrophils and myeloid cells, catalyzes microsomal ω-hydroxylation of LTB4, interacts with CD11b and myeloperoxidase, and regulates cellular development in bone marrow.
- CYP4F3B – liver isoform, catalyzes conversion of arachidonic acid to 20-HETE, a potent PKC activator, implicated in cell proliferation, vascular tone, and natriuresis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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