Thermo Fisher Scientific PSMC4 Polyclonal Antibody

Applications

Tested Dilution

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE
• Sequence homology:
  Cow: 100%
  Dog: 100%
  Guinea Pig: 93%
  Horse: 93%
  Human: 100%
  Mouse: 93%
  Rabbit: 100%
  Rat: 100%

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of a 20S core and a 19S regulator.

• The 20S core consists of four rings of 28 non-identical subunits (two rings of 7 alpha and two rings of 7 beta subunits).
• The 19S regulator includes a base (6 ATPase and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits).
  Proteasomes are abundant in eukaryotic cells and cleave peptides via an ATP/ubiquitin-dependent, non-lysosomal pathway.
  The immunoproteasome plays a key role in processing class I MHC peptides.
  This gene encodes one of the ATPase subunits of the triple-A family, which exhibit chaperone-like activity.
  The subunit interacts with a nuclear hormone receptor and gankyrin, a liver oncoprotein.
  Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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