Thermo Fisher Scientific ERI1 Monoclonal Antibody (OTI1B3), TrueMAB
ERI1 단백질을 표적으로 하는 Mouse IgG2b 단클론 항체로 Western blot 및 IHC에 적합. HEK293T 세포에서 생산된 full-length human ERI1 단백질로 면역원 제작. 액상 형태로 제공되며, -20°C에서 보관. RNA 및 히스톤 mRNA 분해 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B3 |
| Immunogen | Full length human recombinant protein of human ERI1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RNA exonuclease that binds to the 3′-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2′ and 3′-hydroxyl groups at the last nucleotide of the histone 3′-end are required for efficient degradation of RNA substrates. Also able to degrade the 3′-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5′-ACCCA-3′ sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3′-end processing. Also binds to 5.8S ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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