Thermo Fisher Scientific CD7 Polyclonal Antibody

Applications and Tested Dilution

• Application: Western Blot (WB)
• Tested Dilution: 0.5–2 µg/mL

Product Specifications

Product Specific Information

• The immunizing peptide corresponds to a part of the extracellular domain.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, while the carboxy-terminal region is proline-rich and may form a stalk projecting the Ig domain.
CD7 is expressed on most immature and mature T-lymphocytes, T cell leukemia cells, and natural killer cells, as well as a small subset of normal and malignant B cells.
Cross-linking of surface CD7 modulates T cell and NK cell activity, affecting calcium flux, adhesion molecule expression, cytokine secretion, and proliferation.
CD7 associates with phosphoinositol 3-kinase, and its ligation induces D-3 phosphoinositide production and tyrosine phosphorylation.
Expression of CD7 serves as an important marker in leukemia diagnostics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.