Thermo Fisher Scientific PTRF Monoclonal Antibody (1F7)
Human PTRF 단백질을 인식하는 Mouse IgG2b 단일클론 항체. IHC(P) 및 ELISA에 최적화된 연구용 항체. Unconjugated 형식으로 제공되며, 고순도 친화 크로마토그래피 정제. PBS(pH 7.4) 저장, -20°C 보관.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 3 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F7 |
| Immunogen | PTRF (NP_036364, 233 a.a. ~ 321 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
KKAFSKEKME KTKVRTRENL EKTRLKTKEN LEKTRHTLEK RMNKLGTRLV PAERREKLKT SRDKLRKSFT PDHVVYARSK TAVYKVPPF
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts.
PTRF also localizes to caveolae at the plasma membrane and plays a critical role in caveolae formation and caveolin stabilization, translocating from caveolae to the cytoplasm after insulin stimulation.
It is also involved in lipid metabolism and insulin-regulated gene expression. Mutations in this gene are associated with generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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