Thermo Fisher Scientific GUCY1A3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which serves as a peptide hormone receptor.
The GC-C protein consists of an extracellular domain, a single transmembrane domain, and a cytoplasmic region with a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa form on the plasma membrane.
Ligand binding to the extracellular domain of GC-C promotes cGMP accumulation. GC-C acts as the receptor for heat-stable enterotoxins secreted by certain pathogenic E. coli strains that cause severe secretory diarrhea, and also binds guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.