Thermo Fisher Scientific CD44 Monoclonal Antibody (IM7.8.1), Biotin
Mouse CD44 단백질을 인식하는 Biotin-conjugated Rat monoclonal antibody(IM7.8.1). Western blot, IHC, Flow cytometry 등 다양한 응용에 적합. Protein G 정제, PBS/BSA buffer, 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 0.25 µg / 1×10⁶ cells | 1 publication |
| ELISA | Assay-dependent | - |
| Miscellaneous (PubMed) | - | 5 publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IM7.8.1 |
| Immunogen | Mouse CD44 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539260 |
Available Formats
Target Information
CD44 is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, brain white matter, and some epithelial cells. It serves as a receptor for hyaluronic acid (HA) and is involved in cell-cell interaction, adhesion, and migration.
CD44 plays roles in lymphocyte activation, recirculation, and homing. Expression can be upregulated in certain carcinomas and may correlate with metastatic potential.
It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express high CD44 levels, while peripheral B and T cells can upregulate expression upon stimulation.
CD44 gene transcripts undergo complex alternative splicing, producing multiple isoforms with distinct functions. Disorders associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and it may be related to tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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