Thermo Fisher Scientific KCNJ5 Polyclonal Antibody
KCNJ5 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western Blot 및 IHC(Paraffin) 실험에 적합하며, Protein A로 정제된 고순도 항체입니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human KCNJ5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are associated with numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus. Also known as GIRK, Kir3 potassium channels localize to the soma, dendrites, and axons of neurons. Gβγ subunits from G protein heterotrimers bind to and regulate Kir3 channel activity. Gβ3- and Gβ4-containing Gβγ dimers increase K⁺ current, while Gβ5-containing dimers inhibit it. Kir3 channel activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, leading to phosphorylation of Kir3 tyrosine residues and inactivation of the channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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