Thermo Fisher Scientific ZMYM2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Suggested positive control: rat lung tissue lysate
• PA5-21090 can be used with blocking peptide PEP-1204
• The immunogen is located within amino acids 120–170 of ZMYM2

Target Information

ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain, and a C-terminal nuclear localization signal (NLS) and acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of the ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT1, STAT3, and STAT5. This fusion protein is oncogenic and associated with atypical myeloproliferative disease, peripheral blood eosinophilia, and T-cell leukemia/lymphoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.