Thermo Fisher Scientific AXIN2 Polyclonal Antibody
AXIN2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow Cytometry에 적합합니다. 인간 시료에 반응하며, 마우스 및 랫에서도 예측 반응합니다. Protein A 및 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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- PA525331
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | – |
| Flow Cytometry (Flow) | 1:10–1:50 | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 816–843 of the C-terminal region of human AXIN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542831 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Axin-related protein AXIN2 plays an important role in regulating the stability of beta-catenin in the Wnt signaling pathway. In mouse, conductin organizes a multiprotein complex including APC, beta-catenin, and GSK3-beta, leading to beta-catenin degradation. Deregulation of beta-catenin is implicated in various malignancies. The AXIN2 gene, mapped to 17q23–q24, shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in AXIN2 are associated with colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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