Thermo Fisher Scientific alpha + beta Synuclein Polyclonal Antibody
인간, 생쥐, 랫트, 제브라피쉬에 반응하는 rabbit polyclonal 항체로 alpha 및 beta Synuclein을 인식합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며 고순도 Protein A 정제 제품입니다. 신경퇴행성 질환 연구용으로 최적화된 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human alpha + beta Synuclein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and breast cancer.
- In AD, a peptide derived from alpha synuclein forms a component of plaque amyloid.
- In PD, alpha synuclein accumulates in Lewy bodies, and certain alleles are linked to familial PD cases.
- In breast cancer, increased expression of gamma synuclein correlates with disease progression.
Synucleins are also involved in membrane plasticity in the developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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