Thermo Fisher Scientific CYP2D6 Polyclonal Antibody
CYP2D6 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체로 약물 대사 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 283–328 of Human CYP2D6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719228 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
CYP2D6 localizes to the endoplasmic reticulum and metabolizes approximately 20% of commonly prescribed drugs.
Substrates include:
- Debrisoquine (adrenergic-blocking drug)
- Sparteine and propafenone (anti-arrhythmic drugs)
- Amitryptiline (anti-depressant)
The CYP2D6 gene is highly polymorphic; certain alleles result in poor metabolizer phenotypes. It is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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