Thermo Fisher Scientific HIP2 Polyclonal Antibody
HIP2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 시료에 반응하며, Protein A 정제 및 1 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human HIP2 (amino acids 51–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HIP2 (Ubiquitin-conjugating enzyme E2 K) accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, it catalyzes the synthesis of Lys-48-linked polyubiquitin chains, mediating selective degradation of short-lived and abnormal proteins such as those involved in ER-associated degradation (ERAD). It ubiquitinates huntingtin and may influence foam cell formation by regulating apoptosis through p53/TP53 degradation. HIP2 is also proposed to participate in NF-kappa-B processing and may be involved in viral infection-related degradation of MHC class I heavy chains and RB1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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