Thermo Fisher Scientific DFNA5 Polyclonal Antibody
DFNA5/GSDME 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간 및 생쥐에 반응하며, WB, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제된 1 mg/mL 액상 항체로, 연구용으로만 사용 가능.
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Thermo Fisher Scientific DFNA5 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human DFNA5 (Accession O60443), corresponding to amino acid residues L403–A453 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853308 |
Product Specific Information
Antibody detects endogenous levels of total DFNA5/GSDME.
Target Information
DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein expressed in cochlea tissue, placenta, brain, heart, liver, lung, and pancreas as two alternatively spliced isoforms (short and long).
Defects in the DFNA5 gene cause non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of hearing loss resulting from damage to sound-receiving structures in the brain.
The DFNA5 gene maps to human chromosome 7, which contains over 1,000 genes (~5% of the human genome). Defects in genes on chromosome 7 have been associated with Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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