Thermo Fisher Scientific NPR2 Monoclonal Antibody (1E4)
NPR2 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot, IHC, ELISA 등에 적합합니다. 인간 단백질에 반응하며 PBS 용액 형태로 제공됩니다. 연구용으로만 사용되며, 고순도 친화 크로마토그래피로 정제되었습니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL |
| ELISA | 3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E4 |
| Immunogen | NPR2 (NP_003986.2, 131–230 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AKNDHYRTLV RTGPSAPKLG EFVVTLHGHF NWTARAALLY LDARTDDRPH YFTIEGVFEA LQGSNLSVQH QVYAREPGGP EQATHFIRAN GRIVYICGPL
Target Information
This gene encodes natriuretic peptide receptor B (NPR2), one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains:
- Extracellular ligand-binding domain
- Single membrane-spanning region
- Intracellular protein kinase homology domain
- Helical hinge region (involved in oligomerization)
- Carboxyl-terminal guanylyl cyclase catalytic domain
NPR2 is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity.
Mutations in this gene are known to cause acromesomelic dysplasia, Maroteaux type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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