Thermo Fisher Scientific GRASP1 Monoclonal Antibody (OTI2C11)
GRASP1 단백질을 인식하는 mouse IgG1 단일클론 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. 인간 시료 반응성, 액상 형태(0.5 mg/mL), PBS 기반 안정화 버퍼 포함. 신경세포 내 GRASP-1 관련 신호전달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C11 |
| Immunogen | Full length human recombinant protein of GRIPAP1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724397 |
Target Information
PDZ domain-containing proteins such as PSD-95 and GRIP are involved in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) bind to distinct PDZ domains within GRIP and play key roles in regulating glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Research indicates that GRASP-1 may regulate neuronal ras signaling and contribute to AMPA receptor distribution controlled by NMDA receptor activity (Ye et al., 2000).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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