Thermo Fisher Scientific Pannexin 1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Pannexin 1. Validated for WB and IHC with high specificity. Lyophilized form, reconstituted with deionized water. Suitable for research use only, not for diagnostic applications.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400 |
| Immunohistochemistry (IHC) | 1:300 |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide (C)KEPTEPKFKGLRLE, corresponding to amino acid residues 18–31 of human Pannexin 1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736320 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins and is highly conserved in invertebrates and mammals.
Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels.
Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is more distantly related.
PANX1 forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum.
It may function as a Ca²⁺-leak channel to regulate ER Ca²⁺ homeostasis and control neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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