Thermo Fisher Scientific PKC gamma Polyclonal Antibody
PKC gamma 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(F) 실험에 적합합니다. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 0.55 mg/mL 농도의 액상 제품으로, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–166 of Human PKC gamma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.55 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1 M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2545208 |
Product Specific Information
- Recommended positive controls: Molt-4, mouse brain, rat brain
- Predicted reactivity: Mouse (98%), Rat (98%), Rabbit (98%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in structure, tissue distribution, subcellular localization, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family, whose activities are Ca²⁺- and phospholipid-dependent.
PKC family members phosphorylate a wide variety of protein targets and are involved in diverse signaling pathways. PKC gamma is expressed solely in the brain and spinal cord, localized to neurons, and is required for neuronal functions such as long-term potentiation (LTP) and long-term depression (LTD). Knockout studies suggest involvement in neuropathic pain development. Defects in PKC gamma are associated with spinocerebellar ataxia-14 (SCA14).
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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