Thermo Fisher Scientific FAT4 Polyclonal Antibody
Human FAT4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)와 ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 글리세롤 기반 완충액에 보관됩니다. 종특이성은 Human이며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FAT4. Recombinant protein control fragment (Product # RP-101703) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641518 |
Product Specific Information
Immunogen sequence:
FDDPDNIPPY GDDMTVRKQP EGNPKPDIIE RENPYLIYDE TDIPHNSETI PSAPLASPEQ EIEHYDIDNA SSIAPSDADI IQHYKQFRSH T
Antigen sequence identity:
- Mouse: 97%
- Rat: 97%
Target Information
FAT1, FAT2, FAT3, and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergoes proteolytic cleavage by Furin and is predicted to undergo a second cleavage by secretase to release the intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane-associated guanylate kinase MPP5/PALS1. It plays a role in maintaining PCP and inhibiting cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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