Thermo Fisher Scientific FAT4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FAT4. Recombinant protein control fragment (Product #RP-101703). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FAT4,uniProtId:Q6V0I7-1,ncbiNodeId:9606,antigenRange:4556-4646,antigenLength:4981,antigenImageFileName:PA5-62694_FAT4_Q6V0I7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62694_FAT4_Q6V0I7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641518

Product Specific Information

Immunogen sequence: FDDPDNIPPY GDDMTVRKQP EGNPKPDIIE RENPYLIYDE TDIPHNSETI PSAPLASPEQ EIEHYDIDNA SSIAPSDADI IQHYKQFRSH T

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Target Information

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.