Thermo Fisher Scientific SOAT1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE LKPF
• Highest antigen sequence identity:
  Mouse - 59%, Rat - 67%

Target Information

SOAT1 (Sterol O-acyltransferase-1), also designated ACAT1, is a homotetrameric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A (acyl-CoA).
The human SOAT1 gene maps to chromosome 1 and encodes a protein localized in the endoplasmic reticulum of tissues including liver, kidney, adrenal glands, and macrophages.
SOAT1 plays a key role in cellular cholesterol homeostasis and foam cell formation, contributing to atherosclerosis progression.
Several SOAT inhibitors have been developed for atherosclerosis treatment.
SOAT2 (Sterol O-acyltransferase-2), also known as ACAT2, participates in lipoprotein assembly and cholesterol esterification in mammalian cells.
SOAT2 deficiency is associated with severe mental retardation and hypotonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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