Thermo Fisher Scientific QDPR Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human QDPR. Recombinant protein control fragment (Product #RP-101362). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:QDPR,uniProtId:P09417-1,ncbiNodeId:9606,antigenRange:163-239,antigenLength:244,antigenImageFileName:PA5-63632_QDPR_P09417-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63632_QDPR_P09417-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646181

Product Specific Information

Immunogen sequence: SLAGKNSGMP PGAAAIAVLP VTLDTPMNRK SMPEADFSSW TPLEFLVETF HDWITGKNRP SSGSLIQVVT TEGRTEL

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.

Target Information

This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.