Thermo Fisher Scientific DLL3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  LVCACAPGYM GARCEFPVHP DGASALPAAP PGLRPGDPQR YLLPPALGLL

• Storage recommendation:
  For short term use, store at 2–8°C up to 1 week.
  For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Predicted homology:
  Cow: 86%
  Human: 100%
  Mouse: 79%
  Pig: 93%

Target Information

Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway and inhibits primary neurogenesis. It plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1). Mutations in DLL3 can lead to truncal shortening relative to the limbs, abdominal protrusion, abnormal spinal curvature, and sometimes a plagiocephaly-torticollis sequence. DLL3 may be required to divert neurons along a specific differentiation pathway.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.