Thermo Fisher Scientific PrP Monoclonal Antibody (1.5D7)
PrP 단백질의 병원성 이성질체 PrPSc를 인식하는 단클론 항체. Western blot, IHC(P/F), Inhibition assay에 사용 가능. Bovine 반응성, Mouse IgG2b 아이소타입. 단백질 G 정제, PBS + 0.1% BSA 보존, 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1.5D7 |
| Immunogen | The monoclonal antibody 1.5D7 recognizes the disease-associated isoform of the prion protein termed PrPSc. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_3091119 |
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein that associates with lipid raft components and functions as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of prion neurodegenerative disorders, such as Creutzfeldt-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has a higher content of beta-sheets and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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