Thermo Fisher Scientific CD1d Monoclonal Antibody (1B1)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Assay-dependent

Flow Cytometry (Flow)

• Dilution: 1:10–1:20
• Publications: 4 references available

Immunoprecipitation (IP)

• Assay-dependent

Product Specifications

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Rat anti-Mouse CD1d antibody, clone 1B1 recognizes mouse CD1d, a glycoprotein expressed on cortical thymocytes, certain T cell leukemias, and various other antigen-presenting cells.

Target Information

CD1d is a heavy chain associated with Beta-2 microglobulin on cortical thymocytes.
Beta-2 microglobulin-independent expression of CD1d has also been demonstrated on human intestinal epithelial cells.
CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins.
The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to MHC proteins and form heterodimers with beta-2-microglobulin.
CD1 proteins mediate presentation of lipid and glycolipid antigens of self or microbial origin to T cells.
The human genome contains five CD1 family genes organized in a cluster on chromosome 1.
CD1 family members differ in localization and specificity for particular lipid ligands.
The CD1d protein localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail.
Diseases associated with CD1D include Mycobacterium malmoense and Autoimmune Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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