Thermo Fisher Scientific DRAM Polyclonal Antibody

Thermo Fisher Scientific DRAM Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is expected to react with canine, monkey, and opossum samples based on sequence homology.

Target Information

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy — a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, which together promote a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests autophagy may play a more significant role in cancer than previously thought. At least two isoforms of DRAM are known to exist.

Notes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.