Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P)에서 사용 가능. 인간 DRAM의 50–100번 잔기 기반 합성 펩타이드로 제작. 개, 원숭이, 주머니쥐 시료에서도 반응 예상. 액상 형태로 제공되며 4°C 또는 -20°C에서 보관.
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Thermo Fisher Scientific DRAM Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 50–100 of human DRAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1074111 |
Product Specific Information
This antibody is expected to react with canine, monkey, and opossum samples based on sequence homology.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy — a process that degrades cytosolic proteins and organelles. Activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, which together promote a full cell death response. DRAM alone cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests autophagy may play a more significant role in cancer than previously thought. At least two isoforms of DRAM are known to exist.
Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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