Thermo Fisher Scientific SATB2 Monoclonal Antibody (OTI7E11), TrueMAB
SATB2 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western Blot 및 IHC(Paraffin)에 적합합니다. 인간 시료 반응성이 있으며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, 안정적 PBS/BSA/glycerol 버퍼 구성.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7E11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 447–733 of human SATB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold-associated regions. It recognizes the sugar-phosphate structure of double-stranded DNA and functions as a transcription factor controlling nuclear gene expression. SATB2 binds to matrix attachment regions (MARs) of DNA, inducing local chromatin-loop remodeling and recruiting chromatin remodeling enzymes such as HDACs and HATs to promoters and enhancers.
SATB2 is essential for initiating upper-layer neuron (UL1) specific gene programs and modulating BCL11B expression. It acts as a repressor of Ctip2 and regulates corticocortical connections in developing cerebral cortex. Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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