Thermo Fisher Scientific TCL1A Monoclonal Antibody (3G5)
인간 TCL1A 단백질을 인식하는 마우스 단클론 항체. ELISA 및 면역침전(IP)에 사용 가능. 비결합형 액상 포맷으로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA | 10 µg/mL |
| Immunoprecipitation (IP) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G5 |
| Immunogen | TCL1A (NP_068801.1, 61 a.a. – approximately 114 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
Target Information
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T-cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (Virgilio et al., 1998).
In normal T cells, TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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