Thermo Fisher Scientific COMMD10 Polyclonal Antibody

Thermo Fisher Scientific COMMD10 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))
  • Tested Dilution: 1:20–1:50

Product Specifications

Product Specific Information

Immunogen sequence:
QETVEKFRQR ILAPCKLETV GWQLNLQMAH SAQAKLKSPQ AVLQLGVNNE DSKSLEKVLV EFSHKELFDF Y

Highest antigen sequence identity to the following orthologs:

• Mouse: 87%
• Rat: 89%

Target Information

The COMMD family represents a group of evolutionarily conserved proteins sharing a common COMM domain at their C-terminus, which mediates protein-protein interactions. COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein belonging to the COMMD family. It maps to human chromosome 5, which contains approximately 181 million base pairs and accounts for nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or the entire chromosome 5 is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. COMMD10 may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and down-regulate NF-kappa-B activation (PubMed:21778237).

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.