Thermo Fisher Scientific COMMD10 Polyclonal Antibody
Rabbit polyclonal antibody targeting human COMMD10 protein. Validated for IHC (paraffin) with 1:20–1:50 dilution range. Purified by antigen affinity chromatography and supplied in PBS with glycerol. Suitable for research use only.
- 카탈로그번호
- PA560998
- 판매단위
- pk
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Thermo Fisher Scientific COMMD10 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COMMD10. Recombinant protein control fragment (Product #RP-100165). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640037 |
Product Specific Information
Immunogen sequence:
QETVEKFRQR ILAPCKLETV GWQLNLQMAH SAQAKLKSPQ AVLQLGVNNE DSKSLEKVLV EFSHKELFDF Y
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 89%
Target Information
The COMMD family represents a group of evolutionarily conserved proteins sharing a common COMM domain at their C-terminus, which mediates protein-protein interactions. COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein belonging to the COMMD family. It maps to human chromosome 5, which contains approximately 181 million base pairs and accounts for nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or the entire chromosome 5 is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. COMMD10 may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and down-regulate NF-kappa-B activation (PubMed:21778237).
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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