Thermo Fisher Scientific COMMD10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human COMMD10. Recombinant protein control fragment (Product #RP-100165). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:COMMD10,uniProtId:Q9Y6G5-1,ncbiNodeId:9606,antigenRange:118-188,antigenLength:202,antigenImageFileName:PA5-60998_COMMD10_Q9Y6G5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60998_COMMD10_Q9Y6G5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640037

Product Specific Information

Immunogen sequence: QETVEKFRQR ILAPCKLETV GWQLNLQMAH SAQAKLKSPQ AVLQLGVNNE DSKSLEKVLV EFSHKELFDF Y

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 89%.

Target Information

The COMMD family represents a group of evolutionary conserved proteins that share a common COMM domain at their extreme C-terminus, which provides an interface for protein-protein interactions. COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein that belongs to the COMMD family and contains one COMM domain. The gene encoding COMMD10 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.