Thermo Fisher Scientific Phospho-TK1 (Tyr181) Polyclonal Antibody
Thymidine Kinase 1(TK1) 인산화 Tyr181 부위를 인식하는 Rabbit Polyclonal 항체입니다. Western blot 및 IHC(P)에서 사용 가능하며, Human, Mouse, Rat에 반응합니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TK1 (Accession P04183), corresponding to amino acid residues around phosphorylated Tyr181 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816878 |
Product Specific Information
This antibody detects endogenous levels of Thymidine Kinase 1 (TK1) only when phosphorylated at Tyr181.
Target Information
Thymidine Kinase (TK1) is a highly conserved phosphotransferase present in most living cells.
It catalyzes the phosphorylation reaction:
deoxythymidine + ATP → deoxythymidine 5′-phosphate + ADP
TK1 participates in DNA synthesis by introducing deoxythymidine into DNA.
It is essential for the activity of antiviral drugs such as azidothymidine (AZT) and is used in hybridoma selection for monoclonal antibody production.
Clinically, TK1 is expressed primarily during cell division, making it a useful proliferation marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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