Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI2C1), TrueMAB
TLK2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P) 검증 완료. 인간 시료에 반응하며, Affinity chromatography로 정제된 1 mg/mL 액상 제품. PBS/BSA/glycerol buffer에 보관하며, 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–296 of human TLK2 produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation and other cellular processes such as intracellular signaling, protein phosphorylation, cell cycle control, chromatin modification, and DNA damage response.
TLK2 activity peaks during the S phase of the cell cycle and is regulated by phosphorylation. Inhibition of DNA replication leads to rapid loss of TLK2 activity, indicating its tight link to DNA replication. TLK2 is inactivated by phosphorylation at Ser-750, potentially by CHK1, and forms heterodimers with TLK1.
This nuclear protein is widely expressed in fetal placenta, liver, kidney, pancreas, heart, skeletal muscle, and various adult cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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