Thermo Fisher Scientific CNGB3 Polyclonal Antibody
CNGB3 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간 및 생쥐 시료에 반응하며, 액상 형태로 제공됩니다. 친화성 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CNGB3 (Accession Q9NQW8), corresponding to amino acid residues N90–R140 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853101 |
Product Specific Information
This antibody detects endogenous levels of total CNGB3.
Target Information
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as a second messenger. This protein can be activated by cGMP, leading to the opening of the cation channel and depolarization of rod photoreceptors. It induces flickering channel gating, weakens outward rectification in the presence of extracellular calcium, increases sensitivity to L-cis diltiazem, and enhances cAMP efficiency when coexpressed with CNGA3. CNGB3 is essential for generating light-evoked electrical responses in red-, green-, and blue-sensitive cones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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