Thermo Fisher Scientific STAT5b Monoclonal Antibody (12A1)
STAT5b 단백질을 표적으로 하는 Rabbit monoclonal antibody (Clone 12A1). Western blot, IHC(P), ICC/IF에 사용 가능. 고순도 액상형 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12A1 |
| Immunogen | Recombinant human STAT5b protein (around 500–600 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, then form homo- or heterodimers that translocate to the cell nucleus to act as transcription activators.
This protein mediates signal transduction triggered by ligands such as IL2, IL4, CSF1, and various growth hormones. It is involved in processes including TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression.
Additionally, this gene can fuse with the retinoic acid receptor-alpha (RARA) gene in a subset of acute promyelocytic leukemias (APLL). Dysregulation of its signaling pathways may contribute to APLL pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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