Thermo Fisher Scientific SRPK2 Polyclonal Antibody
SRPK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot과 ELISA에 사용 가능하며, 고순도 Affinity Chromatography로 정제되었습니다. 액상 형태로 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 420–520 of human SRPK2 (NP_872633.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855841 |
Product Specific Information
Immunogen sequence:
NAESDYTYSS SYEQFNGELP NGRHKIPESQ FPEFSTSLFS GSLEPVACGS VLSEGSPLTE QEESSPSHDR SRTVSASSTG DLPKAKTRAA DLLVNPLDPR N
Target Information
SRPK2, along with SRPK1, is most likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection. It represents an important host cell target for therapeutic intervention in HBV infection.
Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression via phosphorylation of SRSF2, leading to suppression of p53/TP53 phosphorylation.
Phosphorylates ACIN1 and redistributes it from nuclear speckles to nucleoplasm, resulting in cyclin A1 up-regulation.
Plays an essential role in spliceosomal B complex formation through phosphorylation of DDX23/PRP28.
Negatively regulates HBV replication by reducing packaging efficiency of pgRNA without affecting viral core particle formation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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