Thermo Fisher Scientific IL24 Monoclonal Antibody (OTI4H4)
IL24 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 파라핀 포매 조직 면역조직화학에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. IL-24 관련 신호전달 연구 및 암세포 성장 억제 메커니즘 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 52–206 of IL24 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723288 |
Target Information
Interleukin 24 (IL-24), also known as melanoma differentiation-associated gene-7 (mda-7), encodes a secreted protein homologous to the interleukin 10 (IL-10) cytokine family.
Human IL-24 is secreted by activated peripheral blood mononuclear cells and binds to heterodimeric receptors IL-22R1/IL-20R2 and IL-20R1/IL-20R2, activating JAK/STAT signaling pathways.
Mda-7/IL-24 selectively induces growth suppression, apoptosis, and radiosensitization in malignant gliomas in a p53-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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