Thermo Fisher Scientific PGRMC2 Polyclonal Antibody
Thermo Fisher Scientific의 PGRMC2 Polyclonal Antibody는 인간 PGRMC2 단백질에 특이적인 항체로, WB 및 IHC(P) 실험에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:2,500–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PGRMC2. Recombinant protein control fragment (Product #RP-103756) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645461 |
Product Specific Information
- Immunogen sequence: DLNAVQMESV REWEMQFKEK YDYVGRLLKP GEEPSEYTDE EDTKDHNKQD
- Highest antigen sequence identity to orthologs: Mouse – 98%, Rat – 98%
Target Information
PGRMC2 (progesterone receptor membrane component 2), also known as DG6 or PMBP, is a single-pass membrane protein belonging to the cytochrome b5 family (MAPR subfamily).
Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction.
PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1.
Loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, suggesting a potential role in metastasis suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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