Thermo Fisher Scientific BMPR2 Monoclonal Antibody (2C10)
BMPR2 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot과 ELISA에 적합. 인간 시료 반응성, GST 태그 결합 재조합 단백질 면역원 사용. PBS buffer에 보존제 없이 제공되며 -20°C에서 보관.
- 카탈로그번호
- H00000659-M02
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C10 |
| Immunogen | BMPR2 (NP_001195.2, 939–1037 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein:
NSLDLSATNV LDGSSIQIGE STQDGKSGSG EKIKKRVKTP YSLKRWRPST WVISTESLDC EVNNNGSNRA VHSKSSTAVY LAEGGTATTM VSKDIGMNCTarget Information
BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. BMP ligands are involved in endochondral bone formation and embryogenesis. Loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to primary pulmonary hypertension (PPH). BMPR2 also plays an essential role in human T-cell differentiation.
BMPs signal through heteromeric complexes of type I (50–55 kDa) and type II (70–80 kDa) receptors. Type II receptors bind ligands independently but require type I receptors for signaling, whereas type I receptors depend on type II receptors for ligand binding. Mutations in BMPR2 have been linked to familial and fenfluramine-associated pulmonary hypertension and pulmonary venoocclusive disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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