Thermo Fisher Scientific Caspase 3 p12 Recombinant Rabbit Monoclonal Antibody (23GB3310)
Caspase-3 p12 단백질을 인식하는 토끼 단클론 항체로, Western blot, ICC/IF, Flow Cytometry에 적합합니다. 인체, 생쥐, 랫드 반응성이 있으며, 고순도 정제 및 안정한 PBS/glycerol buffer로 제공됩니다. 연구용으로 세포사멸 관련 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3310 |
| Immunogen | A synthetic peptide of human Caspase-3 p12 (176–277 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The Caspase-3 gene encodes a cysteine-aspartic acid protease (caspase) family member that plays a crucial role in the execution phase of cell apoptosis. Caspases are synthesized as inactive proenzymes that undergo proteolytic processing to generate active subunits forming the functional enzyme. Caspase-3 cleaves and activates caspases 6, 7, and 9, and is itself activated by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta precursor protein, associated with neuronal death in Alzheimer’s disease. Alternative splicing results in two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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