Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI2G3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended product: Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and necessary for glucose transporter expression. It phosphorylates and activates MAPK14/p38-MAPK.
Activation occurs via insulin and RAS oncogene expression, leading to constitutive MAPK14 activation and oncogenic transformation.
Inhibition of MAP2K3 is linked to the pathogenesis of Yersinia pseudotuberculosis.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.