Thermo Fisher Scientific NUP160 Polyclonal Antibody
NUP160 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C에서 보관하며, 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1050 and 1100 of human nucleoporin 160 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and cytoplasm. The mammalian nucleoporin (NUP)-160 is part of a hetero-oligomeric complex that also includes NUP107, NUP133, NUP96, and a mammalian homolog of yeast Sec13p.
While most of the NUP107–160 sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and spindle poles during mitosis, associated with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107–160 complex results in defective spindle assembly, indicating multiple functional roles. NUP160 has also been identified as an HIV dependency factor (HDF), suggesting potential as a drug target in HIV treatment. Multiple isoforms of NUP160 exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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