Thermo Fisher Scientific IFIT3 Recombinant Rabbit Monoclonal Antibody (HL246)
Recombinant rabbit monoclonal antibody HL246 targeting human IFIT3. Validated for WB, IHC, and ICC applications. High purity Protein A–purified IgG with 1 mg/mL concentration. Suitable for research use in antiviral and cell signaling studies.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL246 |
| Immunogen | Recombinant fragment of human IFIT3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093035 |
Target Information
IFIT3 is an IFN-induced antiviral protein that inhibits cellular and viral processes including migration, proliferation, signaling, and viral replication. It enhances MAVS-mediated antiviral responses by bridging TBK1 to MAVS, activating TBK1 and IRF3, which subsequently promotes antiviral gene transcription. IFIT3 exhibits antiproliferative activity by upregulating cell cycle inhibitors CDKN1A/p21 and CDKN1B/p27. It sequesters COPS5 in the cytoplasm, increasing nuclear CDKN1B/p27 levels, and downregulates MYC to enhance CDKN1A/p21 expression. IFIT3 can also negatively regulate the apoptotic effects of IFIT2.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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